RGS Expression Rate-Limits Recovery of Rod Photoresponses
نویسندگان
چکیده
منابع مشابه
RGS Expression Rate-Limits Recovery of Rod Photoresponses
Signaling through G protein-coupled receptors (GPCRs) underlies many cellular processes, yet it is not known which molecules determine the duration of signaling in intact cells. Two candidates are G protein-coupled receptor kinases (GRKs) and Regulators of G protein signaling (RGSs), deactivation enzymes for GPCRs and G proteins, respectively. Here we investigate whether GRK or RGS governs the ...
متن کاملRGS Expression Level Precisely Regulates the Duration of Rod Photoresponses
Regulators of G protein signaling (RGS) constitute a family of proteins that bind specifically to the activated alpha subunits of G proteins (Galpha-GTP), acting as GTPase activating proteins, or GAPs, for the rate of GTP hydrolysis. In this issue of Neuron, Krispel et al. resolve a long-standing puzzle in phototransduction, establishing that RGS9 "GAPping" of G(t)alpha-GTP is the molecular mec...
متن کاملRod photoresponses in 6-week and 4-month-old human infants
Rod-only electroretinograms (ERGs) were recorded from 6-week and 4-month-old normal human infants. The leading edge of the rod a-wave was fitted with a model of the activation phase of phototransduction to provide estimates of S (a sensitivity parameter) and RmP3 (the maximum saturated photoreceptor response) at each of the investigated ages. Both S and RmP3 increased over the first postnatal m...
متن کاملRecovery of the rod photoresponse in infants.
PURPOSE To study deactivation of the rod photoresponse in infants using a paired-flash procedure. Rhodopsin content increases and scales the parameters of the activation of rod phototransduction as rods develop. However, little is known about the kinetics of deactivation in the rods of young infants. METHODS ERG responses to pairs of flashes were used to study the recovery of the rod response...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2006
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2006.07.010